Our main focus is to understand the molecular organization and function of chromatin, the DNA-protein complex which organizes the eukaryotic genome and regulates gene expression, using a combination of chemistry and biophysics.

Positions:

There are open positions for PhD students! If you are interested to perform a PhD thesis on the chemical biology and biophysics of chromatin, directly contact: beat.fierz@epfl.ch

NEWS

December 2018: We thank the Novartis Foundation for Biomedical Research for funding our project investigating molecular mechanisms of DNA repair regulation!
 

 
November 2018: We are excited to have been awarded an SV-iPhD grant, together with the Suter lab (UPSUTER) on pioneer TF mechanisms!
 
 
September 2018 The LCBM welcomes Kristina Makasheva, a new PhD student!
 
August 2018 It was a great summer school in Chemical Biology! Thanks to all the great speakers and participants for this inspiring event!
 
 
July 2018: Congratulations to Rebeca for successfully defending her Master thesis!
Congratulations to Louise for successfully defending her PhD thesis!
Congratulations to Jade for finishing her apprenticeship in the LCBM and for receiving two prizes by the Labo Ecole!
June 2018: Congratulations to Andreas for successfully defending his PhD!
Congratulations to Mathilde for successfully defending her Master Thesis!
March 2018:
Congrats to Sinan, Iuliia and Carolin for having their paper on the effect of uH2A.X on chromatin structure accepted in Chemical Science!

http://pubs.rsc.org/en/content/articlepdf/2014/SC/C8SC00681D?page=search

February 2018: We welcome Mathilde, a semester student from Paris, to our lab!

We also welcome Rebeca, an EPFL master student!

January 2018:
Our paper in Nature Communications on “Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α” is available online:

https://www.nature.com/articles/s41467-017-02619-5

Congrats to Sinan, Iuliia, Louise and our collaborators from the laboratory of Claus Seidel, University of Düsseldorf!

Our work on chromatin dynamics has been recommended in F1000!

January 2018: The LCBM welcomes a new scientific collaborator, Ruud Hovius!
November 2017:
Our paper in Cell Chemical Biology on “Engineered Multivalent Sensors to Detect Coexisting Histone Modifications in Living Stem Cells” is online:

http://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(17)30389-6

Our paper has been highlighted in a Perspective in Cell Chemical Biology: 

https://www.sciencedirect.com/science/article/pii/ S2451945618300035

October 2017:
Our paper in Nature Struct. & Mol. Biol. on “DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation” is out:

https://www.nature.com/articles/nsmb.3488

The paper has also been highlighted in Science Magazine’s Editor’s choice section:

http://science.sciencemag.org/content/358/6365/twil

September 2017:
Congrats to Aurore for having successfully defended her PhD thesis!
August 2017:
Congrats to Nora and Carolin to have their paper on the synthesis of nucleosomes containing asymmetrically modified H4 published in Chem Commun!

http://pubs.rsc.org/en/content/articlehtml/2017/cc/c7cc06180c

We welcome Anne-Marinette Cao and Karthik Maddi, two new postdocs in our lab!
July 2017:
Congrats to Louise and Daniel (LCSB) for having their paper accepted in Nucleic Acids Research!

https://academic.oup.com/nar/article/4064210/Single-molecule-kinetic-analysis-of-HP1-chromatin

June 2017:

The LCBM welcomes a new member, Eduard Ebberink, a post-doctoral fellow, who will work on a collaborative project in the NCCR Chemical Biology.

We are happy that Maxime stays for a PhD after successfully finishing his Master Thesis.

May 2017:
Cover image NRG Our review on Chromatin dynamics has been published in Nature Reviews Genetics (on the cover!):

https://www.nature.com/articles/nrg.2017.28

April 2017:
The SNF has funded our proposal on elucidating the dynamic of pioneer transcription factor interaction with chromatin fibers!
December 2016:
Logo ERC Beat Fierz and the LCBM has been funded by an ERC consolidator grant for the project titled:

Chromo-SUMMIT: Decoding dynamic chromatin signaling by single-molecule multiplex detection

September 2016:

The LCBM welcomes Iuliia, a new postdoctoral fellow! Goodbye to Carolin, good luck in your new job!

July 2016: Congratulations to Maeva for winning the “special price for best presentation” for her apprenticeship project!
June 2016: Congratulations to Ninad for winning the poster prize at the NCCR chemical biology symposium
Logo NCCR
March 2016: The LCBM welcomes a new member, Nora Guidotti
February 2016: The LCBM welcomes Maxime Mivelaz, a NCCR project student
January 2016:
Carolin’s paper is now online in Angewandte Chemie

Traceless synthesis of asymetrically modified bivalent nucleosomes, 10.1002/anie.201510996

December 2015: Congrats to Carolin and Ninad for having their manuscript accepted as a “Hot Paper” in Angewandte Chemie!
October 2015: Congrats to Nora Guidotti for winning the BASF Award for the best master thesis in chemistry!
September 2015: Congrats to Sinan for winning the Student Award for Best Talk, at the 21st PicoQuant Single Molecule Workshop!
August 2015:
Logo SystemsX Our thanks to SystemsX for funding our collaborative project with the group of Vassily Hatzimanikatis.
July 2015:
lLogo Summer school The Summer School on Molecular and Chemical Mechanisms in Epigenetics has concluded. We thank all participants for this great meeting.

Pictures can be found here: http://isic3.epfl.ch/summer-school-2015/index.html

June 2015:
Graphical Abstract Nat Commun Check out our newest publication in Nature Communications:

Multivalency governs HP1α association dynamics with the silent chromatin state

18 Jun 2015 | doi:10.1038/ncomms8313

Our article has been highlighted in a Spotlight in ACS Chemical Biology

http://pubs.acs.org/doi/10.1021/acschembio.5b00516

March 2015:
Congrats to Caroline for receiving a DFG postdoctoral fellowship!

Logo DFG

Congrats to Louise for passing her first year exam!

January 2015: Congrats to Nora for obtaining a Masters degree! Congrats to Andreas for passing his first year exam!

September 2014: The LCBM welcomes a new member, Ninad Agashe, who will work on a collaborative project in the NCCR Chemical Biology.
Logo NCCR
The LCBM welcomes Nora Guidotti, a new Master student.
July 2014: Congrats to Aurore for passing her first year exam!
March 2014: The LCBM welcomes a new member, Louise Bryan.
February 2014: We congratulate Maude for successfully completing her Master’s thesis! The LCBM welcomes a new member, Andreas Bachmann.
January 2014: The LCBM welcomes our new postdoctoral fellow, Carolin Lechner!
November 2013: Congrats to Sinan for passing his first year exam!
October 2013: The LCBM welcomes our new scientific collaborator, Horst Pick
September 2013: The LCBM receives its first SNF grant, to set up a biophysical platform to profile dynamic chromatin effector interactions!
Logo SNF
The LCBM welcomes Maude Meystre, she will be doing her Master project with us.
August 2013: The LCBM welcomes our new member, Aurore Delachat.
July 2013: Goodbye to Ahmed Boumezbeur, who just finished his Master Thesis in the LCBM
July 2013: Congrats to Sinan Kilic for receiving a Boehringer Ingelheim Fonds PhD fellowship!
Logo BIF
April 2013: Congrats to Ahmed Boumezbeur for his Poster Prize at the 9th Epigenetics Course at the Curie Institute!