Our main focus is to understand the molecular organization and function of chromatin, the DNA-protein complex which organizes the eukaryotic genome and regulates gene expression, using a combination of chemistry and biophysics.
There are open positions for PhD students! If you are interested to perform a PhD thesis on the chemical biology and biophysics of chromatin, directly contact: firstname.lastname@example.org
We have also openings for Postdoctoral fellows!
|Check out the new review with the Michael Poirier on chromatin dynamics in Annual Review of Biophysics!|
|Check our our new review on the chemical biology and biophysics of chromatin silencing in Curr. Opin. Chem. Biol.!|
|Check out the preprint of our new study on how pioneer transcription factors can invade compact chromatin fibers and destabilize promoter nucleosomes!|
|Congrats to Nora and our former members Andreas and Carolin for having their paper accepted in ChemBioChem in the ChemBioTalents special issue!|
|We thank the Novartis Foundation for Biomedical Research for funding our project investigating molecular mechanisms of DNA repair regulation!|
|We are excited to have been awarded an SV-iPhD grant, together with the Suter lab (UPSUTER) on pioneer TF mechanisms!|
|September 2018||The LCBM welcomes Kristina Makasheva, a new PhD student!|
|It was a great summer school in Chemical Biology! Thanks to all the great speakers and participants for this inspiring event!|
|July 2018:||Congratulations to Rebeca for successfully defending her Master thesis!|
|Congratulations to Louise for successfully defending her PhD thesis!|
|Congratulations to Jade for finishing her apprenticeship in the LCBM and for receiving two prizes by the Labo Ecole!|
|June 2018:||Congratulations to Andreas for successfully defending his PhD!|
|Congratulations to Mathilde for successfully defending her Master Thesis!|
|Congrats to Sinan, Iuliia and Carolin for having their paper on the effect of uH2A.X on chromatin structure accepted in Chemical Science!|
|February 2018:||We welcome Mathilde, a semester student from Paris, to our lab!
We also welcome Rebeca, an EPFL master student!
|Our paper in Nature Communications on “Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α” is available online:
Congrats to Sinan, Iuliia, Louise and our collaborators from the laboratory of Claus Seidel, University of Düsseldorf!
|Our work on chromatin dynamics has been recommended in F1000!|
|January 2018:||The LCBM welcomes a new scientific collaborator, Ruud Hovius!|
|Our paper in Cell Chemical Biology on “Engineered Multivalent Sensors to Detect Coexisting Histone Modifications in Living Stem Cells” is online:|
|Our paper has been highlighted in a Perspective in Cell Chemical Biology:|
|Our paper in Nature Struct. & Mol. Biol. on “DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation” is out:
The paper has also been highlighted in Science Magazine’s Editor’s choice section:
|Congrats to Aurore for having successfully defended her PhD thesis!|
|Congrats to Nora and Carolin to have their paper on the synthesis of nucleosomes containing asymmetrically modified H4 published in Chem Commun!|
|We welcome Anne-Marinette Cao and Karthik Maddi, two new postdocs in our lab!|
|Congrats to Louise and Daniel (LCSB) for having their paper accepted in Nucleic Acids Research!|
The LCBM welcomes a new member, Eduard Ebberink, a post-doctoral fellow, who will work on a collaborative project in the NCCR Chemical Biology.
We are happy that Maxime stays for a PhD after successfully finishing his Master Thesis.
|Our review on Chromatin dynamics has been published in Nature Reviews Genetics (on the cover!):|
|The SNF has funded our proposal on elucidating the dynamic of pioneer transcription factor interaction with chromatin fibers!|
|Beat Fierz and the LCBM has been funded by an ERC consolidator grant for the project titled:
Chromo-SUMMIT: Decoding dynamic chromatin signaling by single-molecule multiplex detection
The LCBM welcomes Iuliia, a new postdoctoral fellow! Goodbye to Carolin, good luck in your new job!
|July 2016:||Congratulations to Maeva for winning the “special price for best presentation” for her apprenticeship project!|
|June 2016:||Congratulations to Ninad for winning the poster prize at the NCCR chemical biology symposium|
|March 2016:||The LCBM welcomes a new member, Nora Guidotti|
|February 2016:||The LCBM welcomes Maxime Mivelaz, a NCCR project student|
|Carolin’s paper is now online in Angewandte Chemie:|
|December 2015:||Congrats to Carolin and Ninad for having their manuscript accepted as a “Hot Paper” in Angewandte Chemie!|
|October 2015:||Congrats to Nora Guidotti for winning the BASF Award for the best master thesis in chemistry!|
|September 2015:||Congrats to Sinan for winning the Student Award for Best Talk, at the 21st PicoQuant Single Molecule Workshop!|
|Our thanks to SystemsX for funding our collaborative project with the group of Vassily Hatzimanikatis.|
|The Summer School on Molecular and Chemical Mechanisms in Epigenetics has concluded. We thank all participants for this great meeting.
Pictures can be found here: http://isic3.epfl.ch/summer-school-2015/index.html
|Check out our newest publication in Nature Communications:
18 Jun 2015 | doi:10.1038/ncomms8313
|Our article has been highlighted in a Spotlight in ACS Chemical Biology|
|Congrats to Caroline for receiving a DFG postdoctoral fellowship!
Congrats to Louise for passing her first year exam!
|January 2015:||Congrats to Nora for obtaining a Masters degree! Congrats to Andreas for passing his first year exam!|
|September 2014:||The LCBM welcomes a new member, Ninad Agashe, who will work on a collaborative project in the NCCR Chemical Biology.|
|The LCBM welcomes Nora Guidotti, a new Master student.|
|July 2014:||Congrats to Aurore for passing her first year exam!|
|March 2014:||The LCBM welcomes a new member, Louise Bryan.|
|February 2014:||We congratulate Maude for successfully completing her Master’s thesis! The LCBM welcomes a new member, Andreas Bachmann.|
|January 2014:||The LCBM welcomes our new postdoctoral fellow, Carolin Lechner!|
|November 2013:||Congrats to Sinan for passing his first year exam!|
|October 2013:||The LCBM welcomes our new scientific collaborator, Horst Pick|
|September 2013:||The LCBM receives its first SNF grant, to set up a biophysical platform to profile dynamic chromatin effector interactions!|
|The LCBM welcomes Maude Meystre, she will be doing her Master project with us.|
|August 2013:||The LCBM welcomes our new member, Aurore Delachat.|
|July 2013:||Goodbye to Ahmed Boumezbeur, who just finished his Master Thesis in the LCBM|
|July 2013:||Congrats to Sinan Kilic for receiving a Boehringer Ingelheim Fonds PhD fellowship!|
|April 2013:||Congrats to Ahmed Boumezbeur for his Poster Prize at the 9th Epigenetics Course at the Curie Institute!|